EPSTEIN-BARR VIRUS-ASSOCIATED LYMPHOPROLIFERATIVE DISEASE IN A HEART-LUNG ALLOGRAFT

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Abstract
An unusual posttransplant lymphoproliferative disorder to reported occurring within 6 weeks of a heart-lung transplantation, in a patient with primary exposure to the Epstein-Barr virus. The tumor presented primarily in the lung allograft as a rapidly fatal bronchopneumonia refractory to antimicrobial therapy. The viral genome was detected within the lesion by Southern blot analysis, and a primary infection was confirmed by serologic studies. Restriction fragment length polymorphism analysis using the LAM 4-1214 probe demonstrated that the tumor infiltrate in the allograft lung was derived not from the donor''s bronchial-associated lymphoid tissue but from recipient lymphocytes trafficking through the allograft.