Dysregulation of astrocyte extracellular signaling in Costello syndrome
- 6 May 2015
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Translational Medicine
- Vol. 7 (286) , 286ra66
- https://doi.org/10.1126/scitranslmed.aaa5645
Abstract
Excessive HRAS signaling in Costello syndrome accelerates Ras-specific astroglial development and extracellular matrix accumulation, resulting in premature cortical circuit maturation.Keywords
Funding Information
- NIH New Innovator Award (1DP2OD006507)
- National Institute of Mental Health (R01MH099595)
- Research to Prevent Blindness
- That Man May See, Vision Training Grant (T32 EY007120)
- NIH_National Eye Institute Core Grant for Vision Research (EY002162)
- NIH/NIAMS (5RO1AR062165, DP2 OD007449)
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