Experimental and Clinical Trials of New99mTc-Labeled Hepatobiliary Agents

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Abstract
Several new derivatives of lidocaine were synthesized and used to examine the intra- and extrahepatic bile ducts and gallbladder in baboons and humans. Diisopropyl-IDA [iminodiacetic acid] exhibited approximately twice the bile concentration of 131I-rose bengal during the first hour after injection. p-Butyl-IDA also concentrates moderately well in the bile and has the added advantage of very low excretion into the urine (2%). It seems more effective than the other IDA derivatives at high bilirubin levels.