Synthesis of polymeric derivatives of isoniazid: Characterization and in vitro release from a water-soluble adduct with polysuccinimide.
- 1 January 1989
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 37 (4) , 1106-1108
- https://doi.org/10.1248/cpb.37.1106
Abstract
Coupling of isoniazid with polysuccinimide afforded a water-insoluble polymeric pro-drug; by reaction with ethanolamine it was chemically transformed in a water-soluble adduct. The in vitro release of isoniazid from the drug-polymer adduct was studied by using an artificial stomach wall lipid membrane. The transfer rate constant from simulated gastric juice to simulated plasma was defined and compared with that of an equivalent dose of pure drug.This publication has 1 reference indexed in Scilit:
- pH-Induced Shifts in Ultraviolet Maxima for Determination of Isoniazid and Acetyl Isoniazid in MixturesAnalytical Chemistry, 1960