Maternal–fetal transmission of SIV in macaques: Disseminated adenovirus infection in an offspring with congenital SIV infection

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Abstract
To develop a nonhuman primate model for maternal–fetal transmission of HIV infection, we have inoculated pregnant Macaca nemestrina with uncloned SIVMne. Three animals inoculated during the third trimester delivered healthy infants. One of the three infants, a male born 31 days after the mother was inoculated with SIV, became virus‐positive but failed to produce SIV‐specific antibody and died with overt simian immunodeficiency and disseminated adenovirus (SV20) infection at age six and one‐half months. SIV and adenovirus antigen could be demonstrated by immunohistochemical methods in multiple organ systems.

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