Systemic Treatment of Severe Psoriasis

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Abstract
The pathogenesis of psoriasis, which affects approximately 2 percent of the population of the United States and Northern Europe, remains obscure. It is recognized that the disease is genetically determined, but the precise mode of inheritance has not been defined.Psoriasis is most commonly of the plaque type, manifested by disfiguring erythematous scaling plaques that frequently localize on the extensor aspects of the body, especially the knees and elbows, and on the scalp. It can, however, become more extensive and occasionally affect entire areas of the body, and is then called erythrodermic or exfoliative psoriasis. Patients with extensive disease are . . .