Acute renovascular hypertension in conscious dogs. Interaction of the renin-angiotensin system and sympathetic nervous system in systemic hemodynamics and regional blood flow responses.
- 1 September 1980
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 47 (3) , 356-365
- https://doi.org/10.1161/01.res.47.3.356
Abstract
The effects of acute renovascular hypertension on the sympathetic nervous system, regional blood flow and cardiac function were studied in conscious dogs submitted to renal artery occlusion by inflation of a cuff implanted previously around one renal artery. We then compared the alterations in plasma renin and catecholamine levels and in the various hemodynamic parameters induced by those maneuvers in intact dogs, to those in dogs pretreated with alpha- and beta-adrenergic receptor blockers. Subsequently, the converting enzyme inhibitor teprotide was administered to inhibit angiotensin formation in both experiments. Our results suggest that both the renin-angiotensin system and the sympathetic system contribute to the rise in blood pressure. The hemodynamic changes and alterations in regional blood flows accompanying this acute hypertension appear to be due mostly to the increase in plasma angiotensin, since prior adrenoceptor blockade only attenuated their magnitude but did not alter their direction. However, angiotensin-induced coronary vasoconstriction was observed only in adrenergically blocked but not intact animals, probably because of the protective effect of baroreceptor-mediated reflex sympathetic coronary vasodilation.This publication has 23 references indexed in Scilit:
- Metabolic Control of the CirculationJournal of Clinical Investigation, 1978
- Renin-Angiotensin System Inhibition in Conscious Dogs during Acute HypoxemiaJournal of Clinical Investigation, 1978
- Renin-Angiotensin System Inhibition in Conscious Sodium-Depleted DogsJournal of Clinical Investigation, 1978
- Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamineLife Sciences, 1977
- Accentuated Vascular and Endocrine Response to Sq 20881 in HypertensionNew England Journal of Medicine, 1977
- Reciprocal Influence of Salt Intake on Adrenal Glomerulosa and Renal Vascular Responses to Angiotensin II in Normal ManJournal of Clinical Investigation, 1974
- Factors influencing indices of left ventricle contractility in the conscious dogCardiovascular Research, 1974
- Inhibition of Angiotensin Conversion in Experimental Renovascular HypertensionScience, 1972
- New Tables for Multiple Comparisons with a ControlPublished by JSTOR ,1964
- Analysis of Gas in Biological Fluids by Gas ChromatographyScience, 1959