Agelasine F from a Philippine Agelas sp. Sponge Exhibits in vitro Antituberculosis Activity
- 1 May 2000
- journal article
- letter
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 66 (04) , 364-365
- https://doi.org/10.1055/s-2000-8554
Abstract
Marine sponge samples were collected in Baler, Aurora, Philippines, and extracts were tested for in vitro antituberculosis activity. An orange Agelas sp. sponge yielded the known compound, agelasine F, which inhibited some drug resistant strains of Mycobacterium tuberculosis in vitro at concentrations as low as 3.13 μg/ml. Activity against M. tuberculosis residing within macrophages required concentrations of 13 - 22 μg/ml which was below the IC50 for Vero cells (34 μg/ml).Keywords
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