A Double-Blind Trial of Long-Term Lithium Therapy in Mental Defectives
- 29 January 1974
- journal article
- Published by Royal College of Psychiatrists in The British Journal of Psychiatry
- Vol. 124 (578) , 52-57
- https://doi.org/10.1192/bjp.124.1.052
Abstract
The therapeutic effect of lithium in mania was first described by Cade (1949), but the possibility that lithium could have a prophylactic action in recurrent affective disorders was not suggested until some years later (Hartigan, 1963; Baastrup, 1964). The early studies of the prophylactic action of lithium were open trials, in which both investigator and patient knew that the patient was receiving the drug. More recently, controlled double-blind studies have confirmed these early reports (Melia, 1970; Coppenet al., 1971; Cundallet al., 19712).Keywords
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