Bactericidal Efficacy of a Mixture of Ciprofloxacin, Metronidazole, Minocycline and Rifampicin against Bacteria of Carious and Endodontic Lesions of Human Deciduous Teeth In Vitro

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Abstract
The aim of this study was to clarify the antibacterial efficacy of a mixture of ciprofloxacin, metronidazole and minocycline, with and without the addition of rifampicin (100 μg each/ml), against oral bacteria of children. More than 101 bacteria occurred in samples taken from carious (32 cases) and endodontic (28 cases) lesions, and from periodontal pockets (seven cases). However, none were recovered in vitro in the presence of the mixture. The mixture was also effective against the bacteria of dental plaque formed on deciduous teeth (16 cases). When carious and endodontic lesions on split surfaces of freshly extracted teeth were covered overnight with α-tricalcium phosphate (TCP) cement containing the mixed drugs (1 per cent each; seven cases) or immersed in a solution of the mixed drugs (200 μg each/ml; two cases), no bacteria were recovered from the lesions, indicating that the mixture sterilised the lesions in situ. Topical application of the mixture of the drugs to carious and endodontic lesions, dissolved in water or mixed into dental materials, may be useful in denial treatment for children.

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