Distinctive, rapid, and easy labeling of diffuse plaques in the Alzheimer brains by a new methenamine silver stain
- 1 February 1990
- journal article
- research article
- Published by Springer Nature in Acta Neuropathologica
- Vol. 79 (5) , 569-572
- https://doi.org/10.1007/bf00296119
Abstract
We have developed a new methenamine silver (MS) stain for detecting diffuse plaques distinctively on paraffin-embedded tissue sections of Alzheimer-type dementia, Down'n syndrome, and mentally normal aged brains. This rapid and easy method selectively labels amyloid-related component of senile plaques, but not of kuru plaques found in Gerstmann-Sträussler syndrome. Our MS stain shows almost the same staining pattern as that of the β protein immunostaining with formic acid pretreatment. Therefore, new MS stain is appropriate to routine or screening studies for senile plaques including diffuse plaques.This publication has 10 references indexed in Scilit:
- The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndromeJournal of the Neurological Sciences, 1989
- Diffuse type of senile plaques in the cerebellum of Alzheimer-type dementia demonstrated by? protein immunostainActa Neuropathologica, 1989
- A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by? protein immunostainingActa Neuropathologica, 1988
- IMMUNOHISTOCHEMICAL CONFIRMATION OF CREUTZFELDT-JAKOB DISEASE WITH A LONG CLINICAL COURSE WITH AMYLOID PLAQUE CORE ANTIBODIES1988
- Diffuse type of senile plaques in the brains of Alzheimer-type dementiaActa Neuropathologica, 1988
- METHODS IN LABORATORY INVESTIGATION - FORMIC-ACID PRETREATMENT ENHANCES IMMUNOSTAINING OF CEREBRAL AND SYSTEMIC AMYLOIDS1987
- Senile Dementia of the Alzheimer Type Without Neocortical Neurofibrillary TanglesJournal of Neuropathology and Experimental Neurology, 1987
- Diagnosis of Alzheimer's DiseaseArchives of Neurology, 1985
- NEPHROTIC GLOMERULONEPHRITIS1957