In Vitro Permeability Across Caco-2 Cells (Colonic) Can Predict In Vivo (Small Intestinal) Absorption in Man—Fact or Myth
- 1 January 1997
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 14 (6) , 763-766
- https://doi.org/10.1023/a:1012102522787
Abstract
Purpose. To evaluate and optimize the use of Caco-2 cell monolayers to predict the in vivo absorption of a broad range of compounds in man. Methods. Caco-2 cells are derived from human adenocarcinoma...Keywords
This publication has 12 references indexed in Scilit:
- Transport Properties Are Not Altered across Caco-2 Cells with Heightened TEER Despite Underlying Physiological and Ultrastructural ChangesJournal of Pharmaceutical Sciences, 1996
- Flux Measurements across Caco-2 Monolayers May Predict Transport in Human Large Intestinal TissueJournal of Pharmaceutical Sciences, 1996
- In Vitro Permeability Through Caco-2 Cells is not Quantitatively Predictive of in Vivo Absorption for Peptide-Like Drugs Absorbed via the Dipeptide Transporter SystemPharmaceutical Research, 1996
- Peptide Transporter Function and Prolidase Activities in Caco-2 Cells: A Lack of Coordinated ExpressionJournal of Drug Targeting, 1995
- Transepithelial transport of cholyltaurine by Caco-2 cell monolayers is sodium dependentAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 1993
- Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cellsBiochemical and Biophysical Research Communications, 1991
- Cell cultures as models for drug absorption across the intestinal mucosa.1991
- Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2Biochimica et Biophysica Acta (BBA) - Biomembranes, 1990
- Cell culture techniques for the study of drug transportEuropean Journal of Drug Metabolism and Pharmacokinetics, 1990
- Mechanism of L-α-Methyldopa Transport Through a Monolayer of Polarized Human Intestinal Epithelial Cells (Caco-2)Pharmaceutical Research, 1990