Altered objective audiometry in aminoglycosides-treated human neonates
- 1 August 1980
- journal article
- research article
- Published by Springer Nature in European Archives of Oto-Rhino-Laryngology
- Vol. 228 (3) , 205-210
- https://doi.org/10.1007/bf00454229
Abstract
To detect the eventual ototoxicity of aminoglycoside treatments in neonates, we compared brain stem response audiometry (BSRA) recordings in 15 neonates treated i.m. with either Gentamicin or Tobramycin at conventional dosages to those of 14 neonates used as a control group. All babies were housed in incubators and were comparable in gestational age (from 29 to 42 weeks). At day 0, BSRA did not significantly differ in the two groups, 90 dB latencies of the prominent wave V measured at 8.51±0.99 ms in the treated babies and 7.89 ± 0.84 ms in the controls (p > 0.10), respectively. After 5 days of aminoglycoside treatment, the latencies of the wave V dwelled on 9.13 ± 1.90 ms while remaining at 7.75 ± 1.11 ms in the control group (p < 0.01). At day 10 latencies reached 8.73 ± 1.47 ms in treated babies as compared 17.31 ± 1.06 ms in controls (p < 0.01). Short aminoglycoside treatments given to neonates at conventional dosages appeared to alter the acoustically evoked potentials.Keywords
This publication has 18 references indexed in Scilit:
- Temporary threshold shifts in humans exposed to octave bands of noise for 16 to 24 hoursThe Journal of the Acoustical Society of America, 1979
- Detection of Tobramycin- and Netilmicin-Induced Ototoxicity in Guinea Pigs with Evoked Action PotentialsThe Journal of Infectious Diseases, 1979
- Brain Stem Evoked Response Audiometry in Newborn Hearing ScreeningJAMA Otolaryngology–Head & Neck Surgery, 1979
- Clinical Applications of the Auditory Brain Stem ResponseOtolaryngologic Clinics of North America, 1978
- Properties of auditory brainstem evoked responses.1976
- EFFECTS OF INCUBATOR NOISE ON THE COCHLEA OF THE NEWBORNThe Lancet, 1976
- Interaction of Neomycin with Phosphoinositide Metabolism in Guinea Pig Inner Ear and Brain TissuesAnnals of Otology, Rhinology & Laryngology, 1974
- Anatomy And Physiology Of The Onset Of Auditory FunctionActa Oto-Laryngologica, 1973
- Combined Effects of Noise and KanamycinAnnals of Otology, Rhinology & Laryngology, 1971
- AUDITORY-EVOKED FAR FIELDS AVERAGED FROM THE SCALP OF HUMANSBrain, 1971