GROWTH IN SILVER DWARF MICE, WITH AND WITHOUT INJECTIONS OF ANTERIOR PITUITARY EXTRACTS

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Abstract
Physiological studies on the effects of a gene, such as the one for dwarfism in mice, are liable to error from a failure to control the other genes with which the particular one is associated. The untreated Silver dwarf mice held as immediate controls for a previous study fully substantiate the significance of the wt. increases reported to result from treatments with prolactin and various ant. pituitary fractions alone and in combination. Further confirmation is provided by all of the wt. records of untreated Silver dwarfs that have been gathered in this laboratory, covering ages into the 9th mo.; after the 1st mo. there is little evidence of significant growth. The hitherto unreported dosage-response curve for combined pituitary fractions is essentially the same as that earlier observed for the separate fractions. Inj. for 30 days of as little as 1 /xg. daily of 2 recombined ant. pituitary fractions[long dash]one a good prolactin and the other practically free of prolactin[long dash]caused a 30% gain in the body wt. of Silver dwarfs.