IDENTIFICATION OF DRUGS, DRUG METABOLITES, AND OTHER COMPOUNDS IN URINE BY PERMETHYLATION AND GAS-PHASE ANALYSIS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 16  (1) , 145-154
Abstract
A small aliquot of urine (50-200 .mu.l) is evaporated to dryness, the residue permethylated with the methylsulfinylmethide carbanion and methyl iodide, and the product mixture separated and analyzed by GC [gas chromatography] and GC-MS [mass spectrometry]. Certain drugs (especially the anticonvulsants), drug metabolites, mono-, di-, and trisaccharides and organic acids, including fatty acids and glucuronides, can be identified in the mixture. The technique is probably useful mainly as a screening method for the detection of any of these types of compounds in urine.

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