DIBENAMINE
- 1 September 1953
- journal article
- research article
- Published by American Medical Association (AMA) in A.M.A. Archives of Ophthalmology
- Vol. 50 (3) , 289-298
- https://doi.org/10.1001/archopht.1953.00920030296005
Abstract
DIBENAMINE is a nitrogen mustard derivative, first introduced by Nickerson1in 1946, which possesses specific and highly potent sympatholytic and adrenolytic properties. Nickerson and Goodman2subsequently elaborated upon the pharmacological characteristics of the substance. Ophthalmologic interest in the drug was stimulated in 1948 by Christensen, Swan, and Gould,3who reported favorable effects in the treatment of acute glaucoma with Dibenamine. This paper presents certain experimental data concerned with the mechanism of action of Dibenamine in lowering intraocular pressure and our experiences with the drug in the treatment of a small number of patients with acute glaucoma. PURPOSE OF EXPERIMENTS The way in which Dibenamine lowers the intraocular pressure in glaucoma has never been determined. We felt that several possibilities should be investigated and devoted our experimental studies to the following factors: (1) alterations in the permeability of the blood-aqueous barrier; (2) changes in rate of flow ofThis publication has 1 reference indexed in Scilit:
- The Rate of Flow of Aqueous Humor*American Journal of Ophthalmology, 1949