Asymmetric synthesis of mellein methyl ether: use of ortho-toluate carbanions generated by chiral bases
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 14,p. 764-765
- https://doi.org/10.1039/c39830000764
Abstract
An ortho-toluate carbanion generated from (2) by the chiral lithium amide base of (6), (7), or (11) undergoes an enantioselective aldol-type reaction with acetaldehyde to give mellein methyl ether (3), in up to 53% enantiometric excess.Keywords
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