Analytical investigations of cephalosporins. Part 9. Polarographic behaviour of some selected cephalosporins and assay of their formulations
- 1 January 1985
- journal article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 110 (9) , 1111-1115
- https://doi.org/10.1039/an9851001111
Abstract
The polarographic properties of cephalothin, cephacetrile, cefamandole, cefamandole nafate and cefoperazone were investigated by using cathode-ray polarography (CRP) and differential-pulse polarography (DPP). The electroactive group present in the investigated cephalosporins in the R′ leaving group in CH2R′, which is located at the 3-position. The electrochemical methods developed were applied to cephalosporins in dosage forms and a comparison was made with the Ni(II)-hydroxylamine method. The relative standard deviations obtained for the electroanalytical methods varied between 0.28 and 0.95% and for the comparative method between 0.54 and 1.91%.Keywords
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