Use of Kinetic Analysis and Mathematical Modeling in the Study of Metabolic Pathways in Vivo

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Abstract
(Second of Two Parts)SulfobromophthaleinInitial model-based studies of sulfobromophthalein (BSP) dynamics involved investigations in which the plasma disappearance curve of intravenously administered BSP was resolved into two exponential functions. Two pools were postulated, a plasma pool and a hepatic pool.54 , 55 The model permitted analysis of experimental data in terms of the fractional rates of hepatic uptake (a), reflux from liver to plasma (b) and transfer from liver to bile (h).Although fitting the plasma disappearance curves to two exponentials is adequate for the two-compartment model, the model nevertheless represents an oversimplification of BSP metabolism. No provision is made for . . .