Reversible Pseudo-Pelger Anomaly Related to Sulfisoxazole Therapy
- 24 August 1967
- journal article
- case report
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 277 (8) , 421-422
- https://doi.org/10.1056/nejm196708242770810
Abstract
The Pelger-Huët anomaly of granulocytic leukocytes is a benign hereditary disorder1 characterized by poor segmentation and condensation of nuclear chromatin.2 In the heterozygous state the vast majority of nuclei are rodlike or bilobed; in the rare homozygous condition, there is a complete lack of nuclear segmentation, all the nuclei showing a round or slightly indented appearance.3 Morphologic changes resembling the Pelger-Huët anomaly (acquired pseudo-Pelger anomaly) have been described in several myeloproliferative diseases.4 This report deals with a case of acquired pseudo-Pelger anomaly in association with drug fever and rash secondary to the administration of sulfisoxazole (Gantrisin).Case ReportA 27-year-old . . .Keywords
This publication has 4 references indexed in Scilit:
- Acquired Pelger-Huët Granulocytes in Severe MyxedemaActa Haematologica, 1962
- ???ACQUIRED??? PELGER-HU??T CELLS IN BLOOD DYSCRASIASThe Lancet Healthy Longevity, 1960
- Acquired Pseudo-Pelger Anomaly of Granulocytic LeukocytesNew England Journal of Medicine, 1959
- Homozygous Form of Pelger-Huët’s Nuclear Anomaly in ManActa Haematologica, 1952