BIPHASIC PATTERN OF ACTIVATION OF RETICULOENDOTHELIAL SYSTEM BY ANAEROBIC CORYNEFORMS IN MICE

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 32  (3) , 255-264
Abstract
Macrophage activation as measured by increased rates of clearance of C was explored in 5 inbred and 2 outbred strains of mice pretreated with anaerobic coryneform bacilli [Propionibacterium acnes, Corynebacterium anaerobium, P. avidum]. Constant differences were found according to strain from DBA (lowest response) to Sha-Sha (highest response). The investigation was continued with mice of CBA strain which provided highly reproducible, high-level responses. In this strain activation occurred in 2 phases; an early activation which reached maximum levels at 2 days and attributable to a lipid component of the bacteria; and a late phase, reaching a maximum at 14 days which appeared to coincide with greatly increased weight of the liver and spleen due to infiltration by mononuclear cells. The early phase of macrophage activation is probably due to a lipid extract from the anaerobic coryneforms with chemotactic activity.