Defective cellular immunity associated with chronic mucocutaneous moniliasis and recurrent staphylococcal botryomycosis: immunological reconstitution by allogeneic bone marrow.

  • 1 February 1968
    • journal article
    • Vol. 3  (2) , 153-69
Abstract
Immunological studies were conducted on a young girl with chronic muco-cutaneous moniliasis and staphylococcal botryomycosis. A cellular immune defect was demonstrated in three ways: (1) delayed hypersensitivity reactions could not be elicited with a standard panel of antigens used for assaying this phenomenon, (2) prolonged survivals of both parental and unrelated skin homografts were obtained, and (3) only one-third as many peripheral blood lymphocytes showed effects of stimulation by phytohaemagglutinin ([3H]uridine incorporation and blast transformation) as did normal cells. These results suggested that only about one-third of the patient's cells were capable of a normal immunological or metabolic response.