ENDOTOXIN EFFECT ON THE ISOLATED PERFUSED-RAT-LIVER - FUNCTIONAL AND ULTRASTRUCTURAL OBSERVATIONS
- 1 January 1983
- journal article
- research article
- Vol. 15 (3) , 705-712
Abstract
The effect of Escherichia coli endotoxin on bile flow and hepatic ultrastructure was studied in isolated perfused rat liver. Within 30 min after its addition to the perfusate, endotoxin caused bile flow reduction. Despite this cholestatic effect, parenchymal cell structure did not show impressive changes on EM examination. This feature contrasts with the in vivo findings by others and suggests that the activation of extrahepatic mechanisms may contribute to the endotoxin toxicity for parenchymal cells in vivo.This publication has 13 references indexed in Scilit:
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