ORGAN BLOOD-FLOW, CARDIAC-OUTPUT, ARTERIAL BLOOD-PRESSURE, AND VASCULAR-RESISTANCE IN RATS EXPOSED TO VARIOUS OXYGEN PRESSURES

  • 1 January 1979
    • journal article
    • research article
    • Vol. 50  (3) , 256-263
Abstract
Blood flow in different organs, cardiac output and arterial blood pressure were measured in unanesthetized rats under 1, 2, 3.5, 5, and 7 ATA [atmospheres absolute pressure] O2, during 1st electrical discharge developed at 7 ATA O2 and following decompression. Brain, spinal cord and hypophysis blood flow were reduced after 10 min of exposure to 2, 3.5 and 5 ATA O2 and were normal before and during 1st electrical discharge. Liver and muscle blood flow were significantly reduced under all investigated pressures, while myocardium, lung, kidney and adrenal blood flow remained unchanged except for a significant increase in myocardium and lung blood flow under 1 ATA O2. Cardiac output was significantly decreased while blood pressure was significantly increased under all investigated pressures. The total peripheral resistance increased 36 to 81% at various oxygen pressures. These results are discussed in relation to the possible involvement of hemodynamic changes in awake animals, in the development of the adverse effects of high O2 pressure.

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