Pulmonary Infiltrates and Hypoxemia in Patients with the Acquired Immunodeficiency Syndrome Re-exposed to Trimethoprim-sulfamethoxazole

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Abstract
Fever, hypotension, pulmonary infiltrates, and hypoxemia developed upon re-exposure to trimethoprim-sulfamethoxazole in 2 patients with the Acquired Immunodeficiency Syndrome. This reaction can mimic sepsis or the clinical worsening of underlying pulmonary opportunistic infection. The literature concerning adverse pulmonary effects of trimethoprim-sulfamethoxazole is reviewed.

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