Substituted monocarbon carboranes involving thiol, disulfide or dimethyl sulfide ligands
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in J. Chem. Soc., Dalton Trans.
- No. 1,p. 119-126
- https://doi.org/10.1039/dt9920000119
Abstract
New sulfur-substituted derivatives of closo- and nido-monocarbon carboranes have been synthesised for their potential application in 10B neutron capture therapy of tumours. The compounds 7-Me3N-4(6)-HS-nido-7-CB10H11 and 4,4′-, 6,6′- and 4,6′-S2(7-Me3N-nido-7-CB10H11)2 were obtained by Friedel-Crafts substitution of 7-Me3N-nido-7-CB10H12 with S2Cl2; high-temperature boron insertion and methylation of the products gave 1-Me2N-2-Me2S-closo-1-CB11H10 as a result of a cluster rearrangement process. Its structure has been confirmed by X-ray crystallography.Keywords
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