Comparative in vitro activity of A-56268 (TE-031), a new macrolide antibiotic
- 1 February 1987
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 6 (1) , 103-108
- https://doi.org/10.1007/bf02097212
Abstract
The in vitro activity of A-56268 (TE-031) was determined by either standard agar dilution or macrobroth tube dilution and comapred with erythromycin and other antimicrobial agents against 329 clinical aerobic and anaerobic bacterial isolates. A-56268 showed good to excellent in vitro activity against methicillin-sensitiveStaphylococcus aureus,Neisseria meningitidis, and most anaerobes tested with the exception ofBacteroides fragilis isolates. A-56268 had relatively poor activity against coagulase-negative staphylococci and methicillin-resistantStaphylococcus aureus. Except forHaemo philus spp., the activity of A-56268 was similar to or more potent than erythromycin against all other isolates tested. A-56268 did not have significant bactericidal activity against any of the isolates examined.This publication has 1 reference indexed in Scilit:
- Method of reliable determination of minimal lethal antibiotic concentrationsAntimicrobial Agents and Chemotherapy, 1980