On the asymptotic behavior of the estimate of the recombination fraction under the null hypothesis of no linkage when the model is misspecified
- 1 January 1990
- journal article
- research article
- Published by Wiley in Genetic Epidemiology
- Vol. 7 (5) , 309-318
- https://doi.org/10.1002/gepi.1370070502
Abstract
We show that under the null hypothesis of no linkage the maximum likelihood estimator of the recombination fraction converges to 1/2 even when the trait-related parameter values in the likelihood function are misspecified. Furthermore, we show that under the null hypothesis of no linkage, but with misspecified trait-related parameter values, the negative of twice the natural logarithm of the likelihood ratio statistic still has a limiting chi-square distribution with 1 degree of freedom.Keywords
This publication has 6 references indexed in Scilit:
- Man bites dog? The validity of maximizing lod scores to determine mode of inheritanceAmerican Journal of Medical Genetics, 1989
- Inferring mode of inheritance by comparison of lod scoresAmerican Journal of Medical Genetics, 1989
- Effects of Misspecifying Genetic Parameters in Lod Score AnalysisBiometrics, 1986
- Asymptotic behaviour of classification maximum likelihood estimatesBiometrika, 1978
- Asymptotic Behaviour of Classification Maximum Likelihood EstimatesBiometrika, 1978