Characterization of Tumor-Specific Transplantation Immunity Reactions in Immunodiffusion Chambers in Vivo

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Abstract
A diffusible, cytostatic factor present in hamsters rendered immune to SV40-stimulated tumor-specific transplantation antigen (TSTA) was studied. The factor appears to be an antibody of the IgG class and is present only in hamsters rendered specifically immune to SV40 tumor transplant. Sonified SV40 cell preparations did not stimulate the appearance of the inhibitory anti-body nor did immunization with heterologous tumor. These findings agree well with results obtained in the SV40–newborn hamster system and in the cell challenge system. Hamsters immunized against SV40–TSTA did not inhibit adenovirus 31 tumor cell growth in chambers although some cross-reactivity was noted between adenovirus 7 and adenovirus 31 TSTA immunization. The existence of a specific immunoglobulin in hamsters rendered immune to SV40 and adenovirus TSTA's provides a convenient assay to rapidly monitoring TSTA immunity. The role of cytostatic antibody in tumor transplant rejection is discussed.

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