Effect of Thermal Trauma on Numbers and Function of T and B Cells from Mouse Spleen

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Abstract
Swiss-Webster female mice were given a moderately severe burn, and studies were carried out on the number and function of T and B cells from the spleens of burned and normal mice. The results showed a significant decrease (p < 0.05) in the number of T and B cells for 2–3 days after burning with a rapid return to normal and a subsequent rise above normal at 14 and 21 days postburn (p < 0.05). In the tests for function, burned mice had a significant decrease in spontaneous mitotic activity of both T and B cells during the 21-day postburn period. When spleen lymphocytes were incubated with purified mitogens, both T and B cells showed a significantly diminished mitotic response in most of the burned animals.

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