C-peptide, insulin and proinsulinlike components in diabetic and nondiabetic human pancreas.

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Abstract
The contents of insulin and C-peptide extractable with acid alcohol from the tail of the pancreas and insulinoma were investigated, using gel filtration in 7 non-diabetics including 2 patients with insulinoma and 8 diabetics. The gel filtration patterns of both C-peptide and insulin in pancreatic extract were fairly stable even after the pancreas had been left for 14 h in room temperature. In non-diabetics, except cases of insulinoma, the content of insulin in pancreas ranged from 1.42-4.56 U [units] per/g and that of C-peptide from 8.76-25.63 .mu.g/g wet pancreas. The proportion of proinsulinlike components (PLC) ranged from 0.01-2.04% of insulin plus PLC. In diabetics insulin content was low and ranged from 0-1.68 U/g and that of C-peptide from 0-14.48 .mu.g/g wet pancreas. In insulinoma, both insulin and C-peptide increased and PLC occupied 5.48 and 5.96%, respectively.

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