Focal Endothelial Cell Degeneration and Proliferative Endarteritis in Trauma-Induced Early Lesions of Necrobiosis Lipoidica Diabeticorum

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Abstract
Microangiopalhy is an essential component in diabetic vascular pathology. We report ultrastructural observations of ballooning degeneration involving isolated endo-thelial cells of cutaneous capillaries, while leaving adjacent cndothclial cells relatively intact in six diabetic patients with early lesions of necrobiosis lipoidica induced by trauma. Focal proliferation of cndothclial cells encroaching upon the vascular lumina (obliterative endar-tcritis) was also observed. Lectin studies on biopsy specimens of older lesíons of neerobiosis lipoidica revealed paucity of dermal blood vessels. These observations enable us to gain further insight into the pathophysiological mechanisms that underlie diabetic microvascular disease.

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