EFFECT OF CERTAIN TISSUE EXTRACTS ON RED BLOOD CELL REGENERATION

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Abstract
Saline and protein-free extracts of the liver, spleen (rabbits or calves) and gastric mucosae (from pig stomachs) were prepared. Rabbits were made anemic by a single bleeding from the heart until ap-prox. 60% of the blood had been removed, the normal red blood count of 5-6 million being lowered to 2.5-3 million by this procedure. Red blood counts, reticulated cell counts, and hemoglobin estimations were used to determine the rate of blood regeneration. The various extracts were administered subcutaneously and their effects on blood regeneration noted. The results indicated that the extracts from gastric mucosae exerted no significant effect; the liver extracts were only slightly beneficial; whereas the spleen extracts were inhibitory.

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