NYSTATIN BINDING BY PROTOPLASTS AND A PARTICULATE FRACTION OF NEUROSPORA CRASSA, AND A BASIS FOR THE SELECTIVE TOXICITY OF POLYENE ANTIFUNGAL ANTIBIOTICS

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Abstract
Protoplasts, and a particulate fraction obtained by differential centrifugation of a Neurospora extract, bind appreciable amounts of nystatin and other polyene antibiotics. The binding particles may have originated from the cell membrane. These results are consistent with the hypothesis that binding of polyene antibodies produces alterations which inhibit the ability of the fungal cell membrane to function as a selectively permeable barrier. Moreover, the absence of any polyene binding by protoplasts of the polyene-sensitive bacterium, Bacillus megaterium. indicates that the selective toxicity of these agents is probably due to the existence of a unique binding component in the membrane of sensitive organism.

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