Congenital Adrenal Hyperplasia

Open Access
Publisher Website
Google Scholar
Abstract
To the Editor: The enzyme deficiencies that cause congenital adrenal hyperplasias are inferred by measuring steroidal precursors and products in the plasma and urine; the enzymes themselves have not been studied directly. A review of the structural organization of these enzymes1 shows that some enzyme deficiencies may be due to lesions in nonenzymatic proteins. In the November 7 issue of the Journal, Peterson et al.2 described careful and thorough steroidal studies in a patient with disorders of 21-hydroxylase, 17a-hydroxylase, and 17,20 desmolase. They suggested that two enzymes — not three — were disordered, since 17a-hydroxylase and 17,20 desmolase represent . . .

This publication has 10 references indexed in Scilit: