Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3
- 28 March 1997
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 275 (5308) , 1930-1933
- https://doi.org/10.1126/science.275.5308.1930
Abstract
The transcription factor NF-AT responds to Ca 2+ -calcineurin signals by translocating to the nucleus, where it participates in the activation of early immune response genes. Calcineurin dephosphorylates conserved serine residues in the amino terminus of NF-AT, resulting in nuclear import. Purification of the NF-AT kinase revealed that it is composed of a priming kinase activity and glycogen synthase kinase-3 (GSK-3). GSK-3 phosphorylates conserved serines necessary for nuclear export, promotes nuclear exit, and thereby opposes Ca 2+ -calcineurin signaling. Because GSK-3 responds to signals initiated by Wnt and other ligands, NF-AT family members could be effectors of these pathways.Keywords
This publication has 20 references indexed in Scilit:
- Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cellsCurrent Biology, 1996
- Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4Nature, 1996
- Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase BNature, 1995
- Inactivation of Glycogen Synthase Kinase-3 by Epidermal Growth Factor Is Mediated by Mitogen-activated Protein Kinase/p90 Ribosomal Protein S6 Kinase Signaling Pathway in NIH/3T3 CellsPublished by Elsevier ,1995
- NF-AT components define a family of transcription factors targeted in T-cell activationNature, 1994
- Controlling Signal Transduction with Synthetic LigandsScience, 1993
- Identification of calcineurin as a key signalling enzyme in T-lymphocyte activationNature, 1992
- Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexesCell, 1991
- Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin ANature, 1991
- Identification of a Putative Regulator of Early T Cell Activation GenesScience, 1988