Human Monocytes Activated by Immunomodulators in Liposomes Lyse Herpesvirus-Infected But Not Normal Cells
- 1 June 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 224 (4652) , 1007-1009
- https://doi.org/10.1126/science.6426057
Abstract
Highly purified peripheral blood monocytes from normal human donors were activated in vitro by incubation with liposomes containing immunomodulators such as recombinant human gamma interferon, human lymphokines, or muramyl dipeptide. The ability of liposomes containing immunomodulators to activate monocytes to a cytotoxic state capable of discriminating between virus-infected and uninfected cells was shown by activated monocytes recognizing and destroying herpes simplex virus type 2-infected cells while leaving uninfected cells unharmed .This publication has 25 references indexed in Scilit:
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