Pyelonephritis V. Role of Serum Bactericidal Activity and Antibody in Acute Pyelonephritis in the Rabbit.

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Abstract
Summary Intravenous injection of rabbits with Str. faecalis produced an acute pyelonephritis which spontaneously resolved in a few weeks. This infection was accompanied by vigorous antibacterial antibody (agglutinating and hemagglutinating) production which was not associated with increase in serum bactericidal activity as tested. There appeared to be no correlation between individual rabbit pre-infection serum bactericidal activity and the quantitative bacteriological findings in the kidney. The difference between the outcome of infection in the rabbit and rat has not been explained by the immunological studies performed.