Synthesis of a Modified Thymidine and Preparation of Precursors of Oligonucleotide Radicals
- 1 January 1994
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1994 (12) , 1003-1004
- https://doi.org/10.1055/s-1994-34974
Abstract
The synthesis of t-butyl thymidyl ketone 13 has been accomplished starting from the substituted thymidine 9. Ketone 13 is a useful building block for the preparation of modified oligonucleotides. Irradiation of oligonucleotide 14a led selectively to cleavage products 15a and 16a.Keywords
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