APEC, An A2-Selective Adenosine Agonist, is a More Potent Locomotor Depressant Than N6-Cyclohexyladenosine
- 1 July 1991
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 10 (5) , 1211-1212
- https://doi.org/10.1080/07328319108047279
Abstract
The locomotor depressant effects of APEC are due to activation of central A2 adenosine receptors, while the depressant effects of NECA are dependent primarily on A1-receptor activation. A variety of potent A1-antagonists, including conjugates of the XAC, were screened as antagonists; 2-thio-CPX and CPT reversed effects of CHA, but not of APEC.Keywords
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