THE EYE IN ADRENAL SYMPATHICOBLASTOMA (NEUROBLASTOMA)

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Abstract
Adrenal sympathicoblastoma, or neuroblastoma, as it is commonly called, is a malignant tumor occurring almost exclusively in infants and children. Burch found that it does rarely occur in adults. The typical cell is an embryonal nerve cell derived from neural ectoderm and is the primary sympathetic cell. Bailey and Cushing used the term sympathicoblasts, applying it to a group of undifferentiated pluripotential cells derived from the ganglion crest. These migrate into the visceral areas to form a primordium of the sympathetic nervous system and finally differentiate into more mature forms, namely the unipolar and the multipolar neuroblasts. This tumor has the same embryonic origin as the medulla of the suprarenal gland and the adjacent sympathetic ganglions and may arise from either. Bailey and Cushing expressed preference for the term sympathicoblastoma because not all cells in the tumor are potentially neuroblasts. Some may differentiate into chromaffin cells. Sympathicoblastoma is a malignant

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