Corneal and lenticular opacities in mentally retarded young adults treated with thioridazine and chlorpromazine

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Abstract
Of 18 mentally retarded institutionalized subjects who had received long-term, high-dose treatment primarily with thioridazine or chlorpromazine, 2 developed definite corneal and lenticular opacities and 2 had equivocal ocular changes. Alternative treatment, including different neuroleptics, should be considered with mentally retarded institutionalized subjects. When this is not possible, subjects should be given periodic evaluation, including annual slit-lamp examination.