Studies on the bromination of pyrimidine. A facile synthesis of 5‐bromopyrimidine
- 1 April 1973
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 10 (2) , 153-157
- https://doi.org/10.1002/jhet.5570100204
Abstract
Three methods for hromination of pyrimidine were investigated: (a) the bromination of pyrimidine hydrochloride in aromatic solvents, (b) the vapor phase bromination of pyrimidine, and (c) the pyrolysis of pyrimidine hydrochloride perbromide. The addition of bromine to a slurry of pyrimidine hydrochloride in nitrobenzene proved to be superior and afforded excellent yields of 5‐bromopyrimidine.Keywords
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