Low-Density Lipoprotein Size, Pravastatin Treatment, and Coronary Events
Open Access
- 26 September 2001
- journal article
- clinical trial
- Published by American Medical Association (AMA) in JAMA
- Vol. 286 (12) , 1468-1474
- https://doi.org/10.1001/jama.286.12.1468
Abstract
Small-size low-density lipoprotein (LDL) cholesterol has been associated with coronary disease in several retrospective case-control studies,1-6 although other studies have not found this association.7-10 In fact, in 2 studies, larger LDL particles were associated with increased risk of coronary disease.7,8 Most prospective studies,11-13 but not all,14 also found that patients with coronary disease are more likely than controls to have smaller LDL particles. However, no study, retrospective or prospective, found that small LDL had independent predictive value after adjustment for standard lipid risk factors.1-6,11-13Keywords
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