ST segment deviation and regional myocardial blood flow during experimental partial coronary artery occlusion

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Abstract
Carbonized radioactive tracer microspheres of 15 ± 5 ö diameter labelled with gamma-emitting nuclides 141Ce and 85Sr were used to determine regional left ventricular blood flow after partial occlusion of the anterior descending coronary artery in dogs. Blood flow was reduced to 25–30% of control using a cuff flowmeter as monitor. Electrocardiograms were recorded from the epicardial surface of the anterior left ventricular wall before and after partial occlusion. During ischaemia, ST segment depression was observed in epicardial sites overlying normal and hyperaemic flow zones at the periphery of the ischaemic lesion, while ST segment elevation was observed in sites overlying low flow zones in the centre of the ischaemic area. Epicardial sites overlying zones with moderate flow reduction demonstrated both ST elevation and ST depression; predominantly ST elevation in sites of lower flow and depression in sites with higher flow.

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