Kinasing and Clipping Down the NF-κB Trail
- 1 April 2005
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 308 (5718) , 65-66
- https://doi.org/10.1126/science.1110902
Abstract
Activation of T cells is a key requirement for a successful innate or adaptive immune response to pathogenic insult. T cell stimulation results in activation of the master transcription factor NF-B by a complicated signaling pathway that is only partially understood. In their Perspective, van Oers and Chen discuss new findings that implicate the kinase PDK1 ( Lee et al.) and a caspase (Su et al.) as crucial players in the T cell signaling pathway that activates NF-B.Keywords
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