Synthesis of an analog of tabtoxinine as a potential inhibitor of D-alanine:D-alanine ligase (ADP forming)
- 1 January 1989
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 32 (1) , 165-170
- https://doi.org/10.1021/jm00121a030
Abstract
The design and synthesis of a potential inhibitor of D-alanine:D-alanine ligase (ADP forming) (EC 6.3.2.4) are described. This enzyme, which catalyzes the second step in the biosynthesis of bacterial peptidoglycan, is believed to generate D-alanyl phosphate as an enzyme-bound intermediate. With tabtoxinine, a potent inhibitor of glutamine synthetase, as a model, .beta.-lactams 9R and 9S were synthesized as potential precursors of a D-alanyl phosphate mimic.This publication has 14 references indexed in Scilit:
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