Anti-inflammatory activity of a dermally applied copper salicylate preparation (Alcusal®)
- 1 April 1980
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 10 (1-2) , 38-47
- https://doi.org/10.1007/bf02024177
Abstract
In rats, dermal (dorsum) application of an ethanolic copper salicylate complex (ECS) in ethanol with glycerol (Alcusal®) effectively suppressed established polyarthritis, carrageenan-induced paw oedema and the inflammatory response to hydroxylapatite microcrystals. These responses appear to be due to some degree of synergism between the copper(II) and salicylate, i.e. not solely due to either species alone. Evidence for transdermal absorption of64Cu from64Cu-ECS is provided. Some safety aspects of this novel drug are discussed.This publication has 31 references indexed in Scilit:
- Reactivity of antiinflammatory and superoxide dismutase active Cu(II)-salicylatesBioinorganic Chemistry, 1978
- Copper-induced generation of superoxide in human red cell membraneBiochemical and Biophysical Research Communications, 1978
- A comparison of the anti-inflammatory effects of copper aspirinate and other copper salts in the rat and guinea pigInflammation Research, 1978
- Pulse radiolytically generated superoxide and Cu(II)-salicylatesBiochemical and Biophysical Research Communications, 1978
- Copper and inflammationInflammation Research, 1978
- Perfusion of intact skin by a saline solution of bis(glycinato) copper(II)Bioinorganic Chemistry, 1977
- Gastric mucus effusion elicited by oral copper compounds: Potential anti-ulcer activityCellular and Molecular Life Sciences, 1976
- Anti-inflammatory drugs, prostaglandins and leucocyte migrationInflammation Research, 1976
- Ambivalent role of copper in inflammatory disordersInflammation Research, 1976
- Chelation in MedicineScientific American, 1966