The Value of Phase 4 Clinical Testing

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Abstract
Since its inception in 1988, the Multicenter Study of Perioperative Ischemia Research Group has examined a number of critical issues concerning the outcomes of cardiac surgery and anesthesia. The group's database is a powerful research tool. Its power derives from the high quality of the participating institutions, the capability of these institutions to recruit a large number of patients, and an absence of potential conflict of interest, in part due to the large number of participating institutions and investigators.In this issue of the Journal, Mangano et al.1 report the findings from a large clinical database built on the data-collection . . .

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