Comparaison chez des rats génétiquement hyperlipoprotéinémiques et des rats normaux, de la captation et de l'incorporation d'acide oléique et de glycérol marqués perfusés en quantité de charge dans le foie isolé

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Abstract
Perfusions of isolated livers from genetically hyperlipoproteinemic Zucker fa/fa and normolipemic Zucker Fa/- rats are performed with loads of [9,10-3H2] oleic acid and [1-14C] glycerol. The hepatic acylglycerols anabolism from these precursors is higher in the fa/fa rat than in the control Fa/- rat. Synthesis by este-rification (of oleic acid) is more increased than de novo synthesis (from glycerol). The increase in lipid anabolism is due to an augmentation of the hepatic cellular mass, but this anabolism is not regulated in the same way than in the normal rat.